Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.
Identifieur interne : 000A14 ( Main/Exploration ); précédent : 000A13; suivant : 000A15Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.
Auteurs : Hana Odeh [États-Unis] ; Kristina L. Hunker ; Inna A. Belyantseva ; Hela Azaiez ; Matthew R. Avenarius ; Lili Zheng ; Linda M. Peters ; Leona H. Gagnon ; Nobuko Hagiwara ; Michael J. Skynner ; Murray H. Brilliant ; Nicholas D. Allen ; Saima Riazuddin ; Kenneth R. Johnson ; Yehoash Raphael ; Hossein Najmabadi ; Thomas B. Friedman ; James R. Bartles ; Richard J H. Smith ; David C. KohrmanSource :
- American journal of human genetics [ 1537-6605 ] ; 2010.
Descripteurs français
- KwdFr :
- Allèles (MeSH), Analyse de mutations d'ADN (MeSH), Animaux (MeSH), Cartographie chromosomique (MeSH), Cytosquelette d'actine (MeSH), Données de séquences moléculaires (MeSH), Femelle (MeSH), Glutarédoxines (composition chimique), Glutarédoxines (génétique), Humains (MeSH), Locus génétiques (génétique), Mutation (génétique), Mâle (MeSH), Oreille interne (physiopathologie), Pedigree (MeSH), Perte d'audition (génétique), Perte d'audition (physiopathologie), Régulation de l'expression des gènes (MeSH), Souches mutantes de souris (MeSH), Souris (MeSH), Structure tertiaire des protéines (MeSH), Séquence conservée (MeSH), Séquence d'acides aminés (MeSH), Séquence nucléotidique (MeSH), Transport des protéines (MeSH), Évolution moléculaire (MeSH).
- MESH :
- composition chimique : Glutarédoxines.
- génétique : Glutarédoxines, Locus génétiques, Mutation, Perte d'audition.
- physiopathologie : Oreille interne, Perte d'audition.
- Allèles, Analyse de mutations d'ADN, Animaux, Cartographie chromosomique, Cytosquelette d'actine, Données de séquences moléculaires, Femelle, Humains, Mâle, Pedigree, Régulation de l'expression des gènes, Souches mutantes de souris, Souris, Structure tertiaire des protéines, Séquence conservée, Séquence d'acides aminés, Séquence nucléotidique, Transport des protéines, Évolution moléculaire.
English descriptors
- KwdEn :
- Actin Cytoskeleton (MeSH), Alleles (MeSH), Amino Acid Sequence (MeSH), Animals (MeSH), Base Sequence (MeSH), Chromosome Mapping (MeSH), Conserved Sequence (MeSH), DNA Mutational Analysis (MeSH), Ear, Inner (physiopathology), Evolution, Molecular (MeSH), Female (MeSH), Gene Expression Regulation (MeSH), Genetic Loci (genetics), Glutaredoxins (chemistry), Glutaredoxins (genetics), Hearing Loss (genetics), Hearing Loss (physiopathology), Humans (MeSH), Male (MeSH), Mice (MeSH), Mice, Mutant Strains (MeSH), Molecular Sequence Data (MeSH), Mutation (genetics), Pedigree (MeSH), Protein Structure, Tertiary (MeSH), Protein Transport (MeSH).
- MESH :
- chemical , chemistry : Glutaredoxins.
- genetics : Genetic Loci, Glutaredoxins, Hearing Loss, Mutation.
- physiopathology : Ear, Inner, Hearing Loss.
- Actin Cytoskeleton, Alleles, Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Conserved Sequence, DNA Mutational Analysis, Evolution, Molecular, Female, Gene Expression Regulation, Humans, Male, Mice, Mice, Mutant Strains, Molecular Sequence Data, Pedigree, Protein Structure, Tertiary, Protein Transport.
Abstract
Recessive mutations at the mouse pirouette (pi) locus result in hearing loss and vestibular dysfunction due to neuroepithelial defects in the inner ear. Using a positional cloning strategy, we have identified mutations in the gene Grxcr1 (glutaredoxin cysteine-rich 1) in five independent allelic strains of pirouette mice. We also provide sequence data of GRXCR1 from humans with profound hearing loss suggesting that pirouette is a model for studying the mechanism of nonsyndromic deafness DFNB25. Grxcr1 encodes a 290 amino acid protein that contains a region of similarity to glutaredoxin proteins and a cysteine-rich region at its C terminus. Grxcr1 is expressed in sensory epithelia of the inner ear, and its encoded protein is localized along the length of stereocilia, the actin-filament-rich mechanosensory structures at the apical surface of auditory and vestibular hair cells. The precise architecture of hair cell stereocilia is essential for normal hearing. Loss of function of Grxcr1 in homozygous pirouette mice results in abnormally thin and slightly shortened stereocilia. When overexpressed in transfected cells, GRXCR1 localizes along the length of actin-filament-rich structures at the dorsal-apical surface and induces structures with greater actin filament content and/or increased lengths in a subset of cells. Our results suggest that deafness in pirouette mutants is associated with loss of GRXCR1 function in modulating actin cytoskeletal architecture in the developing stereocilia of sensory hair cells.
DOI: 10.1016/j.ajhg.2010.01.016
PubMed: 20137774
PubMed Central: PMC2820167
Affiliations:
Links toward previous steps (curation, corpus...)
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Hunker</name></author><author><name sortKey="Belyantseva, Inna A" sort="Belyantseva, Inna A" uniqKey="Belyantseva I" first="Inna A" last="Belyantseva">Inna A. Belyantseva</name></author><author><name sortKey="Azaiez, Hela" sort="Azaiez, Hela" uniqKey="Azaiez H" first="Hela" last="Azaiez">Hela Azaiez</name></author><author><name sortKey="Avenarius, Matthew R" sort="Avenarius, Matthew R" uniqKey="Avenarius M" first="Matthew R" last="Avenarius">Matthew R. Avenarius</name></author><author><name sortKey="Zheng, Lili" sort="Zheng, Lili" uniqKey="Zheng L" first="Lili" last="Zheng">Lili Zheng</name></author><author><name sortKey="Peters, Linda M" sort="Peters, Linda M" uniqKey="Peters L" first="Linda M" last="Peters">Linda M. Peters</name></author><author><name sortKey="Gagnon, Leona H" sort="Gagnon, Leona H" uniqKey="Gagnon L" first="Leona H" last="Gagnon">Leona H. Gagnon</name></author><author><name sortKey="Hagiwara, Nobuko" sort="Hagiwara, Nobuko" uniqKey="Hagiwara N" first="Nobuko" last="Hagiwara">Nobuko Hagiwara</name></author><author><name sortKey="Skynner, Michael J" sort="Skynner, Michael J" uniqKey="Skynner M" first="Michael J" last="Skynner">Michael J. Skynner</name></author><author><name sortKey="Brilliant, Murray H" sort="Brilliant, Murray H" uniqKey="Brilliant M" first="Murray H" last="Brilliant">Murray H. Brilliant</name></author><author><name sortKey="Allen, Nicholas D" sort="Allen, Nicholas D" uniqKey="Allen N" first="Nicholas D" last="Allen">Nicholas D. Allen</name></author><author><name sortKey="Riazuddin, Saima" sort="Riazuddin, Saima" uniqKey="Riazuddin S" first="Saima" last="Riazuddin">Saima Riazuddin</name></author><author><name sortKey="Johnson, Kenneth R" sort="Johnson, Kenneth R" uniqKey="Johnson K" first="Kenneth R" last="Johnson">Kenneth R. Johnson</name></author><author><name sortKey="Raphael, Yehoash" sort="Raphael, Yehoash" uniqKey="Raphael Y" first="Yehoash" last="Raphael">Yehoash Raphael</name></author><author><name sortKey="Najmabadi, Hossein" sort="Najmabadi, Hossein" uniqKey="Najmabadi H" first="Hossein" last="Najmabadi">Hossein Najmabadi</name></author><author><name sortKey="Friedman, Thomas B" sort="Friedman, Thomas B" uniqKey="Friedman T" first="Thomas B" last="Friedman">Thomas B. Friedman</name></author><author><name sortKey="Bartles, James R" sort="Bartles, James R" uniqKey="Bartles J" first="James R" last="Bartles">James R. Bartles</name></author><author><name sortKey="Smith, Richard J H" sort="Smith, Richard J H" uniqKey="Smith R" first="Richard J H" last="Smith">Richard J H. Smith</name></author><author><name sortKey="Kohrman, David C" sort="Kohrman, David C" uniqKey="Kohrman D" first="David C" last="Kohrman">David C. Kohrman</name></author></analytic><series><title level="j">American journal of human genetics</title><idno type="eISSN">1537-6605</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actin Cytoskeleton (MeSH)</term><term>Alleles (MeSH)</term><term>Amino Acid Sequence (MeSH)</term><term>Animals (MeSH)</term><term>Base Sequence (MeSH)</term><term>Chromosome Mapping (MeSH)</term><term>Conserved Sequence (MeSH)</term><term>DNA Mutational Analysis (MeSH)</term><term>Ear, Inner (physiopathology)</term><term>Evolution, Molecular (MeSH)</term><term>Female (MeSH)</term><term>Gene Expression Regulation (MeSH)</term><term>Genetic Loci (genetics)</term><term>Glutaredoxins (chemistry)</term><term>Glutaredoxins (genetics)</term><term>Hearing Loss (genetics)</term><term>Hearing Loss (physiopathology)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Mutant Strains (MeSH)</term><term>Molecular Sequence Data (MeSH)</term><term>Mutation (genetics)</term><term>Pedigree (MeSH)</term><term>Protein Structure, Tertiary (MeSH)</term><term>Protein Transport (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles (MeSH)</term><term>Analyse de mutations d'ADN (MeSH)</term><term>Animaux (MeSH)</term><term>Cartographie chromosomique (MeSH)</term><term>Cytosquelette d'actine (MeSH)</term><term>Données de séquences moléculaires (MeSH)</term><term>Femelle (MeSH)</term><term>Glutarédoxines (composition chimique)</term><term>Glutarédoxines (génétique)</term><term>Humains (MeSH)</term><term>Locus génétiques (génétique)</term><term>Mutation (génétique)</term><term>Mâle (MeSH)</term><term>Oreille interne (physiopathologie)</term><term>Pedigree (MeSH)</term><term>Perte d'audition (génétique)</term><term>Perte d'audition (physiopathologie)</term><term>Régulation de l'expression des gènes (MeSH)</term><term>Souches mutantes de souris (MeSH)</term><term>Souris (MeSH)</term><term>Structure tertiaire des protéines (MeSH)</term><term>Séquence conservée (MeSH)</term><term>Séquence d'acides aminés (MeSH)</term><term>Séquence nucléotidique (MeSH)</term><term>Transport des protéines (MeSH)</term><term>Évolution moléculaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Glutaredoxins</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Glutarédoxines</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Loci</term><term>Glutaredoxins</term><term>Hearing Loss</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutarédoxines</term><term>Locus génétiques</term><term>Mutation</term><term>Perte d'audition</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Oreille interne</term><term>Perte d'audition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Ear, Inner</term><term>Hearing Loss</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Actin Cytoskeleton</term><term>Alleles</term><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Chromosome Mapping</term><term>Conserved Sequence</term><term>DNA Mutational Analysis</term><term>Evolution, Molecular</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Mutant Strains</term><term>Molecular Sequence Data</term><term>Pedigree</term><term>Protein Structure, Tertiary</term><term>Protein Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Analyse de mutations d'ADN</term><term>Animaux</term><term>Cartographie chromosomique</term><term>Cytosquelette d'actine</term><term>Données de séquences moléculaires</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pedigree</term><term>Régulation de l'expression des gènes</term><term>Souches mutantes de souris</term><term>Souris</term><term>Structure tertiaire des protéines</term><term>Séquence conservée</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Transport des protéines</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recessive mutations at the mouse pirouette (pi) locus result in hearing loss and vestibular dysfunction due to neuroepithelial defects in the inner ear. Using a positional cloning strategy, we have identified mutations in the gene Grxcr1 (glutaredoxin cysteine-rich 1) in five independent allelic strains of pirouette mice. We also provide sequence data of GRXCR1 from humans with profound hearing loss suggesting that pirouette is a model for studying the mechanism of nonsyndromic deafness DFNB25. Grxcr1 encodes a 290 amino acid protein that contains a region of similarity to glutaredoxin proteins and a cysteine-rich region at its C terminus. Grxcr1 is expressed in sensory epithelia of the inner ear, and its encoded protein is localized along the length of stereocilia, the actin-filament-rich mechanosensory structures at the apical surface of auditory and vestibular hair cells. The precise architecture of hair cell stereocilia is essential for normal hearing. Loss of function of Grxcr1 in homozygous pirouette mice results in abnormally thin and slightly shortened stereocilia. When overexpressed in transfected cells, GRXCR1 localizes along the length of actin-filament-rich structures at the dorsal-apical surface and induces structures with greater actin filament content and/or increased lengths in a subset of cells. Our results suggest that deafness in pirouette mutants is associated with loss of GRXCR1 function in modulating actin cytoskeletal architecture in the developing stereocilia of sensory hair cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20137774</PMID><DateCompleted><Year>2010</Year><Month>03</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6605</ISSN><JournalIssue CitedMedium="Internet"><Volume>86</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Feb</Month><Day>12</Day></PubDate></JournalIssue><Title>American journal of human genetics</Title><ISOAbbreviation>Am J Hum Genet</ISOAbbreviation></Journal><ArticleTitle>Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.</ArticleTitle><Pagination><MedlinePgn>148-60</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ajhg.2010.01.016</ELocationID><Abstract><AbstractText>Recessive mutations at the mouse pirouette (pi) locus result in hearing loss and vestibular dysfunction due to neuroepithelial defects in the inner ear. Using a positional cloning strategy, we have identified mutations in the gene Grxcr1 (glutaredoxin cysteine-rich 1) in five independent allelic strains of pirouette mice. We also provide sequence data of GRXCR1 from humans with profound hearing loss suggesting that pirouette is a model for studying the mechanism of nonsyndromic deafness DFNB25. Grxcr1 encodes a 290 amino acid protein that contains a region of similarity to glutaredoxin proteins and a cysteine-rich region at its C terminus. Grxcr1 is expressed in sensory epithelia of the inner ear, and its encoded protein is localized along the length of stereocilia, the actin-filament-rich mechanosensory structures at the apical surface of auditory and vestibular hair cells. The precise architecture of hair cell stereocilia is essential for normal hearing. Loss of function of Grxcr1 in homozygous pirouette mice results in abnormally thin and slightly shortened stereocilia. When overexpressed in transfected cells, GRXCR1 localizes along the length of actin-filament-rich structures at the dorsal-apical surface and induces structures with greater actin filament content and/or increased lengths in a subset of cells. Our results suggest that deafness in pirouette mutants is associated with loss of GRXCR1 function in modulating actin cytoskeletal architecture in the developing stereocilia of sensory hair cells.</AbstractText><CopyrightInformation>Copyright (c) 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Odeh</LastName><ForeName>Hana</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunker</LastName><ForeName>Kristina L</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Belyantseva</LastName><ForeName>Inna A</ForeName><Initials>IA</Initials></Author><Author ValidYN="Y"><LastName>Azaiez</LastName><ForeName>Hela</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Avenarius</LastName><ForeName>Matthew R</ForeName><Initials>MR</Initials></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Lili</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Linda M</ForeName><Initials>LM</Initials></Author><Author ValidYN="Y"><LastName>Gagnon</LastName><ForeName>Leona H</ForeName><Initials>LH</Initials></Author><Author ValidYN="Y"><LastName>Hagiwara</LastName><ForeName>Nobuko</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Skynner</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Brilliant</LastName><ForeName>Murray H</ForeName><Initials>MH</Initials></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>Nicholas D</ForeName><Initials>ND</Initials></Author><Author ValidYN="Y"><LastName>Riazuddin</LastName><ForeName>Saima</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Kenneth R</ForeName><Initials>KR</Initials></Author><Author ValidYN="Y"><LastName>Raphael</LastName><ForeName>Yehoash</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Najmabadi</LastName><ForeName>Hossein</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Friedman</LastName><ForeName>Thomas B</ForeName><Initials>TB</Initials></Author><Author ValidYN="Y"><LastName>Bartles</LastName><ForeName>James R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Richard J H</ForeName><Initials>RJ</Initials></Author><Author ValidYN="Y"><LastName>Kohrman</LastName><ForeName>David C</ForeName><Initials>DC</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R29 DC003049</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R29 DC03049</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30-DC05188</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United 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IdType="pubmed">11795590</ArticleId></ArticleIdList></Reference><Reference><Citation>Circ Res. 2008 Mar 28;102(6):711-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18258855</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Mol Cell Biol. 2004 Aug;5(8):635-46</Citation><ArticleIdList><ArticleId IdType="pubmed">15366707</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Cell Biol. 2005 Feb;7(2):148-56</Citation><ArticleIdList><ArticleId IdType="pubmed">15654330</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Genet. 2004 Aug;41(8):591-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15286153</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Cell Biol. 2000 Feb;12(1):72-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10679353</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2000 Aug 11;275(32):24798-806</Citation><ArticleIdList><ArticleId IdType="pubmed">10783391</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Otolaryngol Suppl. 1985;422:1-69</Citation><ArticleIdList><ArticleId IdType="pubmed">3877398</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hum Genet. 2010 Feb 12;86(2):138-47</Citation><ArticleIdList><ArticleId IdType="pubmed">20137778</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Dev Biol. 1999 Jan;43(1):85-90</Citation><ArticleIdList><ArticleId IdType="pubmed">10213086</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Neurosci. 2002 Oct;16(8):1433-41</Citation><ArticleIdList><ArticleId IdType="pubmed">12405956</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Cell Dev Biol. 2008 Dec;19(6):502-10</Citation><ArticleIdList><ArticleId IdType="pubmed">18692583</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 2002 Jun;12(6):996-1006</Citation><ArticleIdList><ArticleId IdType="pubmed">12045153</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Motil Cytoskeleton. 2005 Nov;62(3):157-65</Citation><ArticleIdList><ArticleId IdType="pubmed">16206170</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 2002 Aug 1;11(16):1887-98</Citation><ArticleIdList><ArticleId IdType="pubmed">12140191</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2002 Aug 22;418(6900):837-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12192399</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2003 Jan 1;31(1):383-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12520028</ArticleId></ArticleIdList></Reference><Reference><Citation>Hear Res. 1982 May;7(1):75-89</Citation><ArticleIdList><ArticleId IdType="pubmed">6178719</ArticleId></ArticleIdList></Reference><Reference><Citation>IUBMB Life. 2002 Dec;54(6):351-5</Citation><ArticleIdList><ArticleId IdType="pubmed">12665246</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Motil Cytoskeleton. 2002 Dec;53(4):326-36</Citation><ArticleIdList><ArticleId IdType="pubmed">12378542</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1998 May 29;280(5368):1444-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9603735</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13958-63</Citation><ArticleIdList><ArticleId IdType="pubmed">14610277</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2002 Oct 4;277(40):37590-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12138088</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mol Genet. 2003 Nov 1;12(21):2797-805</Citation><ArticleIdList><ArticleId IdType="pubmed">12966030</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hered. 1946 Nov;37(11):335-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20281716</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurocytol. 2000 Apr;29(4):227-40</Citation><ArticleIdList><ArticleId IdType="pubmed">11276175</ArticleId></ArticleIdList></Reference><Reference><Citation>Dev Biol. 2003 Feb 1;254(1):93-101</Citation><ArticleIdList><ArticleId IdType="pubmed">12606284</ArticleId></ArticleIdList></Reference><Reference><Citation>Protein Sci. 1995 Oct;4(10):1998-2005</Citation><ArticleIdList><ArticleId IdType="pubmed">8535236</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2000 Jun 2;299(2):499-520</Citation><ArticleIdList><ArticleId IdType="pubmed">10860755</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comp Neurol. 2005 Apr 25;485(1):75-85</Citation><ArticleIdList><ArticleId IdType="pubmed">15776440</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2000 Winter;2(4):811-20</Citation><ArticleIdList><ArticleId IdType="pubmed">11213485</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1989 Aug 25;264(24):13963-6</Citation><ArticleIdList><ArticleId IdType="pubmed">2668278</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hered. 1967 Jan-Feb;58(1):21-4</Citation><ArticleIdList><ArticleId IdType="pubmed">6031678</ArticleId></ArticleIdList></Reference><Reference><Citation>Brain Res. 1996 May 20;721(1-2):49-58</Citation><ArticleIdList><ArticleId IdType="pubmed">8793083</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S211-5</Citation><ArticleIdList><ArticleId IdType="pubmed">12874433</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 1997 Apr 25;268(1):78-94</Citation><ArticleIdList><ArticleId IdType="pubmed">9149143</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2002 Dec 5;420(6915):520-62</Citation><ArticleIdList><ArticleId IdType="pubmed">12466850</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 1977 Nov;75(2 Pt 1):339-43</Citation><ArticleIdList><ArticleId IdType="pubmed">318131</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Sci. 1996 Jun;109 ( Pt 6):1229-39</Citation><ArticleIdList><ArticleId IdType="pubmed">8799813</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Oct 26;276(43):40008-17</Citation><ArticleIdList><ArticleId IdType="pubmed">11489904</ArticleId></ArticleIdList></Reference><Reference><Citation>Dev Biol. 1986 Jul;116(1):119-29</Citation><ArticleIdList><ArticleId IdType="pubmed">3732602</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1998 May 29;280(5368):1447-51</Citation><ArticleIdList><ArticleId IdType="pubmed">9603736</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2003 Dec 8;163(5):1045-55</Citation><ArticleIdList><ArticleId IdType="pubmed">14657236</ArticleId></ArticleIdList></Reference><Reference><Citation>Audiol Neurootol. 2004 Sep-Oct;9(5):303-14</Citation><ArticleIdList><ArticleId IdType="pubmed">15347914</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Neurosci. 2009 Jun;12(6):703-10</Citation><ArticleIdList><ArticleId IdType="pubmed">19471269</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2008 Apr;9(4):277-90</Citation><ArticleIdList><ArticleId IdType="pubmed">18283275</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1988 Dec;85(23):8998-9002</Citation><ArticleIdList><ArticleId IdType="pubmed">2461560</ArticleId></ArticleIdList></Reference><Reference><Citation>Dev Biol. 1986 Jul;116(1):100-18</Citation><ArticleIdList><ArticleId IdType="pubmed">3732601</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2002 Mar;30(3):277-84</Citation><ArticleIdList><ArticleId IdType="pubmed">11850618</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Res. 1998 Apr;8(4):354-61</Citation><ArticleIdList><ArticleId IdType="pubmed">9548971</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2000 Aug 4;102(3):377-85</Citation><ArticleIdList><ArticleId IdType="pubmed">10975527</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comp Neurol. 1994 Dec 8;350(2):187-98</Citation><ArticleIdList><ArticleId IdType="pubmed">7884037</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2009 Oct 2;139(1):33-44</Citation><ArticleIdList><ArticleId IdType="pubmed">19804752</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2002 Jan 1;30(1):38-41</Citation><ArticleIdList><ArticleId IdType="pubmed">11752248</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Struct Biol. 1999 Jan;6(1):38-43</Citation><ArticleIdList><ArticleId IdType="pubmed">9886290</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 1997 Sep 1;25(17):3389-402</Citation><ArticleIdList><ArticleId IdType="pubmed">9254694</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Mol Med. 1999 Jun 30;31(2):53-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10410302</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Cell Biol. 2009 Apr;11(4):443-50</Citation><ArticleIdList><ArticleId IdType="pubmed">19287378</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2001 Feb 15;409(6822):860-921</Citation><ArticleIdList><ArticleId IdType="pubmed">11237011</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2004 Feb;6(1):63-74</Citation><ArticleIdList><ArticleId 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Allen</name><name sortKey="Avenarius, Matthew R" sort="Avenarius, Matthew R" uniqKey="Avenarius M" first="Matthew R" last="Avenarius">Matthew R. Avenarius</name><name sortKey="Azaiez, Hela" sort="Azaiez, Hela" uniqKey="Azaiez H" first="Hela" last="Azaiez">Hela Azaiez</name><name sortKey="Bartles, James R" sort="Bartles, James R" uniqKey="Bartles J" first="James R" last="Bartles">James R. Bartles</name><name sortKey="Belyantseva, Inna A" sort="Belyantseva, Inna A" uniqKey="Belyantseva I" first="Inna A" last="Belyantseva">Inna A. Belyantseva</name><name sortKey="Brilliant, Murray H" sort="Brilliant, Murray H" uniqKey="Brilliant M" first="Murray H" last="Brilliant">Murray H. Brilliant</name><name sortKey="Friedman, Thomas B" sort="Friedman, Thomas B" uniqKey="Friedman T" first="Thomas B" last="Friedman">Thomas B. Friedman</name><name sortKey="Gagnon, Leona H" sort="Gagnon, Leona H" uniqKey="Gagnon L" first="Leona H" last="Gagnon">Leona H. 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Peters</name><name sortKey="Raphael, Yehoash" sort="Raphael, Yehoash" uniqKey="Raphael Y" first="Yehoash" last="Raphael">Yehoash Raphael</name><name sortKey="Riazuddin, Saima" sort="Riazuddin, Saima" uniqKey="Riazuddin S" first="Saima" last="Riazuddin">Saima Riazuddin</name><name sortKey="Skynner, Michael J" sort="Skynner, Michael J" uniqKey="Skynner M" first="Michael J" last="Skynner">Michael J. Skynner</name><name sortKey="Smith, Richard J H" sort="Smith, Richard J H" uniqKey="Smith R" first="Richard J H" last="Smith">Richard J H. Smith</name><name sortKey="Zheng, Lili" sort="Zheng, Lili" uniqKey="Zheng L" first="Lili" last="Zheng">Lili Zheng</name></noCountry><country name="États-Unis"><region name="Michigan"><name sortKey="Odeh, Hana" sort="Odeh, Hana" uniqKey="Odeh H" first="Hana" last="Odeh">Hana Odeh</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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